"Be pleasant until ten o'clock in the morning and the rest of the day will take care of itself." ~ Elbert Hubbard

 “Up to 95 percent of the original Native American population, estimated at roughly twenty million people, disappeared after the invasion of European colonizers. While there was direct violence toward Native Americans, many of these deaths can be attributed to the introduction of smallpox. Smallpox is a virus that is spread when one comes into contact with infected bodily fluids or contaminated objects such as clothing or blankets. The virus then finds its way into a person's lymphatic system. Within days of infection, large, painful pustules begin to erupt over the victim's skin.

In school curriculums, this has often been taught as an unfortunate tragedy, an accidental side effect of trade, and therefore a reason to claim that the Europeans did not commit genocide. However, in recent years, many historians have recognized that the spreading of smallpox was an early form of biological warfare, one which was understood and used without mercy from at least the mid-1700s. Noted conversations among army officials include letters discussing the idea of "sending the Small Pox among those disaffected tribes" and using "every stratagem to reduce them." Another official, Henry Bouquet, wrote a letter that told his subordinates to "try to Innoculate [sic] the Indians, by means of Blankets, as well as to Try Every other Method, that can serve to Extirpate this Execrable Race." They followed through on their plan, giving two blankets and a handkerchief from a Smallpox Hospital alongside other gifts to seal an agreement of friendship between the local Native tribes and the men at Fort Pitt, located in what is now western Pennsylvania.”

― Leah Myers, Thinning Blood: A Memoir of Family, Myth, and Identity